Clinical & Prescribing Information
1. Therapeutic Indications & Overview
Cornfyl SR 300 contains a higher dosage of 300mg of natural micronized progesterone in a sustained-release system. It is formulated specifically for clinical situations requiring intense, continuous hormonal support in high-risk pregnancies or assisted reproductive technology (ART) cycles.
Luteal phase support, habitual/threatened abortion, secondary amenorrhea
2. Mechanism of Action
By delivering natural progesterone continuously, it mimics the corpus luteum's hormone production. This relaxes the uterine smooth muscles, prevents premature uterine contractions, and supports the vascular supply of the placenta.
3. Dosage & Administration
One tablet daily or as directed by an obstetrician. The sustained release structure maintains consistent plasma levels, making once-daily dosing optimal.
*Note: The exact dosage schedule must be tailored to the individual clinical response and patient profile under doctor supervision.
4. Clinical Efficacy & Safety Profile
Ideal for women undergoing IVF cycles or those with severe luteal phase deficiency, showing a substantial increase in ongoing pregnancy and live birth rates.
5. Precautions & Contraindications
Monitor patients with pre-existing conditions like diabetes, asthma, epilepsy, migraine, or cardiac impairment closely, as progesterone can cause mild fluid retention.